✦ LIBER ✦

Nonsense suppression in aminoacyl-t-RNA limited cells

✍ Scribed by Gallant, Jonathan ;Erlich, Henry ;Weiss, Robert ;Palmer, Linda ;Nyari, Linda

Book ID: 104725956
Publisher: Springer
Year: 1982
Tongue: English
Weight: 826 KB
Volume: 186
Category: Article
ISSN: 0026-8925
DOI: 10.1007/bf00331853

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✦ Synopsis

A number of nonsense alleles of lacZ exhibit phenotypic suppression (as much as a sixteen-fold increase in leakiness) during partial limitation for certain aminoacyl-tRNA species in relA mutant cells. Each responsive allele has its individual pattern of response to limitation for one or more amino acids or aminoacyl-tRNA's. The phenotypic suppression occurs only during limitation, and ceases once limitation is reversed. Suppression is much reduced by the presence of the relA+ allele or an allele of rpsL which restricts ribosomal ambiguity. In one case, the suppressed product has been identified by radioimmune assay and gel electrophoresis, and is a full-length lacZ protomer. Mechanisms are discussed whereby aberrations of translation at codons calling for an aminoacyl-tRNA species in short supply might lead to readthrough of a nearby nonsense codon.

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