Nonsense mutation of glucokinase gene in late-onset non-insulin-dependent diabetes mellitus
β Scribed by Katagiri, H.; Asano, T.; Ishihara, H.; Inukai, K.; Anai, M.; Yazaki, Y.; Oka, Y.; Miyazaki, J.
- Book ID
- 123403070
- Publisher
- The Lancet
- Year
- 1992
- Tongue
- English
- Weight
- 282 KB
- Volume
- 340
- Category
- Article
- ISSN
- 0140-6736
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Non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes, affecting 5% of the general population. Genetic factors play an important role in the development of the disease. While in other populations NIDDM is usually diagnosed after the fifth decade of life, in Mexico a lar
Mutations were screened for in the glucokinase gene of 25 Japanese patients with Type 2 (non-insulin-dependent) diabetes mellitus. Each exon was scanned by electrophoresis of enzymatically amplified DNA segments under non-denaturing conditions and variants were sequenced. A variant pattern was detec