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Nonpeptide Inhibitors of Cathepsin G: Optimization of a Novel β-Ketophosphonic Acid Lead by Structure-Based Drug Design

✍ Scribed by Greco, Michael N.; Hawkins, Michael J.; Powell, Eugene T.; Almond,, Harold R.; Corcoran, Thomas W.; de Garavilla, Lawrence; Kauffman, Jack A.; Recacha, Rosario; Chattopadhyay, Debashish; Andrade-Gordon, Patricia; Maryanoff, Bruce E.


Book ID
121273474
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
105 KB
Volume
124
Category
Article
ISSN
0002-7863

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Structure-based design of novel nonpepti
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## Abstract A series of novel nonpeptide inhibitors of the pp60^c‐Src^ (Src) SH2 domain is described that exploit multifunctional group replacement of the phenylphosphate moiety of phosphotyrosine (pTyr). Relative to an x‐ray structure of citrate complexed to the pTyr binding site of the Src SH2 do