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Nonlinkage of D6S260, a putative schizophrenia locus, to bipolar affective disorder

✍ Scribed by Adams, Linda J.; Salmon, Judy; Donald, Jennifer A.; Mitchell, Philip B.; Schofield, Peter R.

Book ID: 101214271
Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 251 KB
Volume: 67
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19960920)67:5<485::aid-ajmg9>3.0.co;2-j

No coin nor oath required. For personal study only.

✦ Synopsis

To examine whether genes that predispose to schizophrenia also confer a predisposition to other psychiatric disorders such as bipolar affective disorder (BAD), we tested for linkage between the recently identified schizophrenia susceptibility locus D6S260 and the inheritance of BAD in 12 large Australian pedigrees. W e found no evidence for linkage over a region of 12-27 cM from the D6S260 locus, depending on the model used. Our results therefore do not provide support for the continuum theory of psychosis.

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