✦ LIBER ✦

Nonlinear least-squares regression analysis in pharmacokinetics: Application of a programmable calculator in model parameter estimation

✍ Scribed by Keith T. Muir

Publisher: Elsevier Science
Year: 1980
Tongue: English
Weight: 570 KB
Volume: 13
Category: Article
ISSN: 0010-4809
DOI: 10.1016/0010-4809(80)90024-5

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✦ Synopsis

Two programs allowing nonlinear least-squares fits to data conforming to the onecompartment oral and the two-compartment intravenous pharmacokinetic models are described. Model parameter estimates are obtained together with an estimate of the precision of these parameters. The method is based on the Gauss-Newton algorithm programmed onto a Texas Instruments TI 59 pocket programmable calculator and recorded on 7.5 x 1.5~cm magnetic cards. Comparisons with NONLIN show that the parameter estimates from both programs are essentially identical. The programs allow for a great reduction in computing costs and increased availability of data analysis facilities in phannacokinetics.

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