✦ LIBER ✦
Application of a programmable calculator in data fitting according to one and two compartment open models in clinical pharmacokinetics
✍ Scribed by S. Niazi
- Publisher
- Elsevier Science
- Year
- 1977
- Weight
- 189 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0010-468X
No coin nor oath required. For personal study only.
✦ Synopsis
The plasma or blood concentration profiles are fitted by single or two compartment open models using log-linear regression analyses. For two compartment models, "feathering" is performed at 95% equilibration time obtained from raw pharmacokinetic data. The equations have been programmed onto a Texas Instrument SR 52 pocket calculator and recorded on 8.5 × 1.7 cm magnetic strips, facilitating drug dosage regimen calculations through individual patient titrations in a clinical setting.