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Noninvasive Detection of Graft Rejection by In Vivo 19F MRI in the Early Stage

✍ Scribed by U. Flögel; S. Su; I. Kreideweiß; Z. Ding; L. Galbarz; J. Fu; C. Jacoby; O. Witzke; J. Schrader

Book ID
114805827
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
550 KB
Volume
11
Category
Article
ISSN
1600-6135

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## Abstract A novel MRI proteinase‐modulated contrast agent (PCA) was developed to detect the activity of the proinvasive enzyme matrix metalloproteinase‐2 (MMP‐2) in vivo. The PCA2‐switch agent incorporates a solubility switch, where cleavage of a peptide substrate by MMP‐2 decreases the water sol