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Nonhydrolyzable Phosphotyrosyl Mimetics for the Preparation Of Phosphatase-Resistant SH2 Domain Inhibitors

✍ Scribed by Burke, Terrence R. Jr.; Smyth, Mark S.; Otaka, Akira; Nomizu, Motoyoshi; Roller, Peter P.; Wolf, Gert; Case, Randi; Shoelson, Steven E.


Book ID
111679247
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
678 KB
Volume
33
Category
Article
ISSN
0006-2960

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## Abstract A series of novel nonpeptide inhibitors of the pp60^c‐Src^ (Src) SH2 domain is described that exploit multifunctional group replacement of the phenylphosphate moiety of phosphotyrosine (pTyr). Relative to an x‐ray structure of citrate complexed to the pTyr binding site of the Src SH2 do