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Nonane enhances propranolol hydrochloride penetration in human skin

โœ Scribed by Joseph L. Melendres; Avinash Nangia; Lena Sedik; Mitsuhiko Hori; Howard I. Maibach

Book ID
113366219
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
503 KB
Volume
92
Category
Article
ISSN
0378-5173

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Enhancement of propranolol hydrochloride
Enhancement of propranolol hydrochloride and diazepam skin absorption in vitro: Effect of enhancer lipophilicity
โœ Mitsuhiko Hori; Susumu Satoh; Howard I. Maibach; Richard H. Guy ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 469 KB ๐Ÿ‘ 1 views

The enhancement of model hydrophilic (propranolol hydrochloride) and lipophilic (diazepam) drug penetration across rat and hairless mouse skin in vitro has been studied. Preliminary experiments established that most n-alkanes having chain lengths of between 7 and 16 promote the flux of both drugs. F