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Nonalcoholic Fatty Liver Disease: Pathogenesis and Potential for Nuclear Receptors as Therapeutic Targets

โœ Scribed by George, Jacob; Liddle, Christopher


Book ID
126922195
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
118 KB
Volume
5
Category
Article
ISSN
1543-8384

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Obesity is associated with chronic low-grade inflammation that negatively impacts insulin sensitivity. Here, we show that high-fat diet can increase NF-B activation in mice, which leads to a sustained elevation in level of IB kinase โ‘€ (IKKโ‘€) in liver, adipocytes, and adipose tissue macrophages. IKKโ‘€