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Non-viral neuronal gene delivery mediated by the HC fragment of tetanus toxin

✍ Scribed by Andrew Knight; Jaime Carvajal; Holm Schneider; Charles Coutelle; Sue Chamberlain; Neil Fairweather


Book ID
114429653
Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
705 KB
Volume
259
Category
Article
ISSN
1432-1327

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## Abstract The nontoxic binding domain of tetanus toxin (fragment C or TTC) readily undergoes retrograde axonal transport from an intramuscular injection site. This property has led to investigation of TTC as a possible vector for delivering therapeutic proteins to motor neurons. However, the vast