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Non-viral gene therapy: polycation-mediated DNA delivery

โœ Scribed by M. Thomas; A. M. Klibanov

Publisher
Springer
Year
2003
Tongue
English
Weight
207 KB
Volume
62
Category
Article
ISSN
1432-0614

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Background Efยฎcient and target-speciยฎc in vivo gene delivery is a major challenge in gene therapy. Compared to cell culture application, in vivo gene delivery faces a variety of additional obstacles such as anatomical size constraints, interactions with biological ยฏuids and extracellular matrix, and