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Non-stealth and stealth solid lipid nanoparticles (SLN) carrying doxorubicin: pharmacokinetics and tissue distribution after i.v. administration to rats

✍ Scribed by Anna Fundarò; Roberta Cavalli; Alessandro Bargoni; Daniela Vighetto; Gian Paolo Zara; Maria Rosa Gasco

Book ID
118770870
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
167 KB
Volume
42
Category
Article
ISSN
1043-6618

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Pharmacokinetics and tissue distribution of idarubicin-loaded solid lipid nanoparticles after duodenal administration to rats
✍ Zara, Gian Paolo (author);Bargoni, Alessandro (author);Cavalli, Roberta (author) 📂 Article 📅 2002 🏛 John Wiley and Sons Inc. 🌐 English ⚖ 143 KB

Idarubicin-loaded solid lipid nanoparticles (IDA-SLN) and idarubicin in solution were prepared and the two formulations were administered to rats, either by the duodenal route or intravenously (iv). The aim of this research was to study whether the bioavailability of idarubicin can be improved by ad