✦ LIBER ✦

Non-specific interactions between heparin and poly-l-lysine surfaces

✍ Scribed by P.G. Hartley; A.I. Bailey; P.F. Luckham; G. Batts

Publisher: Elsevier Science
Year: 1993
Tongue: English
Weight: 602 KB
Volume: 77
Category: Article
ISSN: 0927-7757
DOI: 10.1016/0927-7757(93)80116-v

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✦ Synopsis

The surface force apparatus has been used to study the force law between mica surfaces modified with the biopolymers heparin and poly-L-lysine by direct adsorption from solution. Between identical surfaces the interactions were well described by the DLVO theory for repulsive double-layer overlap. Between dissimilar surfaces, strong attractive forces were measured which were consistent with the Hogg-Healy-Fuerstenau approximation to the Poisson-Boltzmann distribution for asymmetric double layers, suggesting a non-specific electrostatic basis for the measured long-range forces.

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