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Non-specific immunosuppression in experimental cryptococcosis in rats

✍ Scribed by Diana T. Masih; Héctor R. Rubinstein; Claudia E. Sotomayor; María E. Ferro; Clelia M. Riera

Publisher
Springer Netherlands
Year
1986
Tongue
English
Weight
436 KB
Volume
94
Category
Article
ISSN
0301-486X

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✦ Synopsis

The delayed type hypersensitivity response to human serum albumin (HSA) of rats infected intraperitoneally with 107 viable C. neoformans cells, and 7 days after, immunized with human serum albumin was significantly diminished (p < 0.05) when compared with the response observed in rats immunized with human serum albumin and non infected. The spleen mononuclear cells from suppressed rats transferred to normal syngeneic recipients of the same sex suppress the afferent phase of the response (p < 0.02) suggesting that cells present in the spleen might be one of the responsible mechanisms for the suppression to nonrelated antigens in infected animals.

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