𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Experimental cryptococcosis in guinea pigs

✍ Scribed by Clelia M. Riera; Diana T. Masih; Rodolfo Nobile

Publisher
Springer Netherlands
Year
1983
Tongue
English
Weight
932 KB
Volume
82
Category
Article
ISSN
0301-486X

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✦ Synopsis

A guinea pig model was used to evaluate immune response to Cryptococcus neoformans. This model shared characteristics with cryptococcosis in humans. Twenty five guinea pigs injected intraperitoneally with 10(7) viable C. neoformans cells developed disseminated disease. Forty days after infection all guinea pigs were killed and autopsy performed. C. neoformans growth in the lungs, brains, livers and spleen of the infected animals were determined. Furthermore, the immune response was characterized by moderate degree of delayed-type hypersensitivity and humoral response. In some organs was observed neutrophil and lymphocyte infiltration with presence of cryptococci cells. The infiltration observed in the organs was probably a consequence of an immune reaction.

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