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Non-radioactive in situ hybridization for mRNA with emphasis on the use of oligodeoxynucleotide probes

✍ Scribed by D. M. Hougaard; Henrik Hansen; Lars-Inge Larsson

Publisher
Springer
Year
1997
Tongue
English
Weight
637 KB
Volume
108
Category
Article
ISSN
1432-119X

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## Background: Immunoreactivity for chromogranin a (cg a) is associated with the presence of neurosecretory granules in tumor cells, but immunohistochemical staining for cg a may be absent in small cell lung carcinoma (sclc), which has only a few secretory granules. localization of cg a mrna is a u

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W e read with great interest the article by Sumiyoshi et al., 1 in which the authors report that the detection of chromogranin A (Cg A) mRNA using a new in situ hybridization method is far more sensitive than immunohistochemistry. In their series, 100% of 20 small cell carcinoma (SCLC) cases were po