Non-mutagenicity of 2-Methyl-2,3-Epoxybutane and factors influencing the mutagenicity of 2,3-Epoxybutane

✍ Scribed by C. De Meester; M. Mercier; F. Poncelet

• Publisher: John Wiley and Sons
• Year: 1982
• Tongue: English
• Weight: 409 KB
• Volume: 2
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/jat.2550020604

✦ Synopsis

Abstract

The compound 2,3‐epoxybutane (2,3‐EB) is a direct mutagen for the base‐pair‐substitution‐sensitive strains TA 1530, TA 1535 and TA 100, in the absence and in the presence of metabolic activation by liver S9‐mix. Under the same experimental conditions, the 2‐methyl derivative of 2,3‐EB was not mutagenic, up to 10 mg per plate. The parent compound (2,3‐EB) was more active on strain TA 1530 in the presence of liver S9‐mix. This was observed at every epoxide concentration tested. The increase of mutagenicity depended on the S9 concentration, the mix composition and to a small extent on the method utilized.