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Non-Linear Effects in Ruthenium-Catalysed Asymmetric Hydrogenation with Atropisomeric Diphosphanes

✍ Scribed by Christian Girard; Jean-Pierre Genêt; Michel Bulliard

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 372 KB
Volume: 1999
Category: Article
ISSN: 1434-193X
DOI: 10.1002/(sici)1099-0690(199911)1999:11<2937::aid-ejoc2937>3.0.co;2-b

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✦ Synopsis

A strong positive nonlinear effect (asymmetric amplification) hydrogenated product with 91% ee. The influence of temperature and hydrogen pressure on this effect are was found to take place during asymmetric hydrogenations using chiral atropisomeric diphosphane-ruthenium catalysts.

presented. These nonlinear effects can be explained on the basis of a hydrogenation mechanism in which diastereomeric As an example, at atmospheric pressure the use of 50% ee BINAP to prepare [(binap)Ru(Br) 2 ] give rise to a dimers as pre-catalytic species are present.

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