Non-enzymatic glycation of peripheral nerve proteins in human diabetics
β Scribed by Catherine Ryle; Michael Donaghy
- Book ID
- 118931888
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 743 KB
- Volume
- 129
- Category
- Article
- ISSN
- 0022-510X
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π SIMILAR VOLUMES
The permeation of native and non-enzymatically glycated albumin and immunoglobulin G into the endoneurium of the sciatic nerve of rats was examined in acute experiments. Low amounts of native albumin entered both in control and streptozotocin-diabetic animals with no significant difference between t
Mass spectrometry has been applied successfully to the study of non-enzymatic protein glycation, which is a topic of wide interest in the diabetes field. Low- and high-resolution mass spectra, GC/MS, and collisional activation spectroscopy allow the structural identification and quantitative evaluat
## Abstract Recent studies on nonβenzymatic protein glycation are reviewed, and results are critically discussed. Advanced glycation end products (AGE) levels in the body reflect a balance between their formation and catabolism. AGE proteolysis leads to the formation of lowβmolecularβweight AGE (AG