Non-enzymatic glycation of histones

✍ Scribed by H. M. Liebich; E. Gesele; C. Wirth; J. Wöl; K. Jobst; A. Lakatos

• Book ID: 101760834
• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 251 KB
• Volume: 22
• Category: Article
• ISSN: 1076-5174
• DOI: 10.1002/bms.1200220204

✦ Synopsis

2-(ZFuroyl)-~2-furanyl)-l~-imidazole (FFI) is detected in total histones and the lysine-rich histone 1 fraction isolated from calf thymus after in vitro glycation and hydrolysis with HCl, using gas chromatogaphic/mass spectrometric analysis. The finding suggests that glucose is bound to the &-amino groups of the lysine residues of the histones. No FFI is monitored in native histone samples.