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Non-destructive Cleavage of N-Acylsultams Under Neutral Conditions: Preparation of Enantiomerically, Pure Fmoc-Protected α-Amino Acids

✍ Scribed by Wolfgang Oppolzer; Phillippe Lienard

Publisher
John Wiley and Sons
Year
1992
Tongue
German
Weight
691 KB
Volume
75
Category
Article
ISSN
0018-019X

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✦ Synopsis

Sultam 1 and its antipode (up to multi-kg scale) and N-{N'-[bis(methylthio)methylidene]glycyl}bornane-10,2-sultam are distributed by: NEWPORT, Synthesic Ireland Ltd., Dublinpreland. 3 3b 1 88 5b 85 7b 78 < 0.5b) 5 4c 2 75 5C 71 ' ) HPLC (chiral column) b, 'H-NMR Analysis

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✍ Josiane Thierry; Chongwei Yue; Pierre Potier 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 197 KB

2-Phenylisopropyl and t-butyl trichloroacetamidates I and 2 are useful reagents for the esterification of N-protected aminoacids under mild neutral conditions. In the case of hydroxylcontaining amino acids, dialkylation occurs but no selectivity could be obtained