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Non-classical regulation of estrogen receptor-α by ICI182,780

✍ Scribed by Michael M. Wang; Richard J. Traystman; Patricia D. Hurn; Tongyun Liu


Book ID
116697444
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
640 KB
Volume
92
Category
Article
ISSN
0960-0760

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Both primary and acquired resistance to the growthinhibitory effects of anti-estrogens (e.g.. tamoxifen) limits the clinical usefulness of these drugs in the treatment of breast cancer. The new, steroidal anti-estrogen ICI 182.780 was tested for its ability to inhibit the proliferation of a tamoxife