Fulvestrant (ICI 182,780) sensitizes breast cancer cells expressing estrogen receptor α to vinblastine and vinorelbine
✍ Scribed by Meihua Sui; Donghai Jiang; Claire Hinsch; Weimin Fan
- Book ID
- 106378337
- Publisher
- Springer US
- Year
- 2009
- Tongue
- English
- Weight
- 706 KB
- Volume
- 121
- Category
- Article
- ISSN
- 0167-6806
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
To elucidate the mechanisms responsible for the development of anti-estrogen resistance, we have cloned and established 3 stable ICI-182,780-resistant sub-lines, MCF-7/182 R -1, MCF-7/182 R -6 and MCF-7/182 R -7 from the estrogen-receptor(ER)-positive and estrogen-responsive human breastcancer MCF-7
We and others have shown previously that retinoic acid (RA) selectively inhibits the growth of estrogen receptor (ER)-positive human breast carcinoma (HBC) cells and ER-negative cells are refractory to RA inhibition o f growth. The ER-negative cells inherently express lower levels of RARa and retino