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Nomenclature for antiviral-resistant human hepatitis B virus mutations in the polymerase region

✍ Scribed by Lieven J. Stuyver; Stephen A. Locarnini; Anna Lok; Douglas D. Richman; William F. Carman; Jules L. Dienstag; Raymond F. Schinazi


Book ID
111721421
Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
266 KB
Volume
33
Category
Article
ISSN
0270-9139

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In vitro evaluation of hepatitis B virus
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Several mutations (V521L, P525L, L528M, T532S, and V555I) in the gene for hepatitis B virus (HBV) polymerase have been identified in HBV isolated from patients that displayed break-through viremia during famciclovir treatment. To determine whether these mutations cause phenotypic resistance to famci