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No TP53 mutations in neuroblastomas detected by PCR-SSCP

✍ Scribed by Javier S. Castresana; M. Josefa Bello; Juan A. Rey; Paloma Nebreda; Antonio Queizán; Furificación García-Miguel; Angel Pestana

Book ID
119106326
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
103 KB
Volume
77
Category
Article
ISSN
0165-4608

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Mutations in the TP53 gene are considered to be among the most common genetic alterations in human cancers. Both somatic and germline mutations have been found. Using polymerase chain reaction (PCR). constant denaturant gel electrophoresis (CDGE), and denaturing gradient gel electrophoresis (DGGE),