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No TP53 mutations in neuroblastomas detected by PCR-SSCP analysis

✍ Scribed by Javier S. Castresana; M. Josefa Bello; Juan A. Rey; Paloma Nebreda; Antonio Queizàn; Purificatión Garcia-Miguel; Angel Pestaña

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
241 KB
Volume
10
Category
Article
ISSN
1045-2257

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✦ Synopsis

We have analyxed 29 neuroblastomas for TP53 mutations in exons 5 to 8 by means of the polymerase chain reaction in combination with the single-strand conformation polymorphism technique. We could not detect any mutation. These results indicate that, in contrast to the majority of tumors so far studied, TP53 mutations do not seem to be important for the development of neuroblastomas.

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