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No evidence of the APC D1822V missense variant's pathogenicity in Tunisian patients with sporadic colorectal cancer

โœ Scribed by K. Bougatef; R. Marrakchi; S. Ouerhani; R. Sassi; A. Moussa; N. Kourda; Y. Blondeau Lahely; T. Najjar; S. Ben Jilani; F. Soubrier; A. Ben Ammar Elgaaied


Book ID
116821780
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
192 KB
Volume
57
Category
Article
ISSN
0369-8114

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โœ Clara Ruiz-Ponte; Ana Vega; Angel Carracedo; Francisco Barros ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 26 KB ๐Ÿ‘ 2 views

Germline mutations in the tumor-suppresor APC gene are associated with hereditary familial adenomatous polyposis (FAP) and somatic mutations are common in sporadic colorectal cancer. In this study, we report the identification of three novel germline mutations: 1682-1683insA, 3252-3253insAT, 3544A>T