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No evidence for the in vivo activity of aromatase-inhibiting flavonoids

✍ Scribed by Niina Saarinen; Suresh C Joshi; Markku Ahotupa; Xiangdong Li; Jenni Ämmälä; Sari Mäkelä; Risto Santti

Book ID
117668208
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
207 KB
Volume
78
Category
Article
ISSN
0960-0760

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Site. -Depending on the reaction time, indan-1-ones (III) and inden-1-ones (V) are prepared. They are further used to study the active binding site of human aromatase inhibitors. Two compounds (Vb) and (Vc) are good inhibitors of human aromatase whereas they weakly inhibit the equine enzyme.