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No evidence for sequences structurally related to the RB1 gene in the human genome

✍ Scribed by Claus Belka; Valerie Greger; Bernhard Zabel; Bernhard Horsthemke

Publisher: Springer
Year: 1991
Tongue: English
Weight: 325 KB
Volume: 86
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00201844

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✦ Synopsis

The retinoblastoma (RB1) gene is a ubiquitously expressed gene encoding a cell-cycle control protein. Inactivation of this gene plays a crucial role in the development of retinoblastoma, osteosareoma, and other tumors. In a search for structurally related gene sequences we identified a 5.5-kb BamHI fragment strongly cross-hybridizing with the 5' end of the RB1 eDNA. Molecular cloning, in situ hybridization, restriction mapping, and sequence analysis identified this DNA segment as the 28S rRNA gene. The absence of other crosshybridizing sequences suggests that the RB1 gene is not part of a structurally related gene family.

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