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No evidence for an allelic association between schizophrenia and markers D22S278 and D22S283

✍ Scribed by Williams, N.M.; Jones, L.A.; Murphy, K.C.; Cardno, A.G.; Asherson, P.; Williams, J.; McGuffin, P.; Owen, M.J.

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 68 KB
Volume: 74
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19970221)74:1<37::aid-ajmg8>3.0.co;2-s

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✦ Synopsis

We report a case control association study using markers D22S278 and D22S283 in 90 unrelated patients with DSMIII-R schizophrenia and 90 controls matched for ethnicity, age and sex. No differences between allele frequencies for either marker were observed when the two groups were compared (D22S278: 2 ‫؍‬ 6.53, df ‫؍‬ 7, P ‫؍‬ 0.51; D22S283: 2 ‫؍‬ 14.73, df ‫؍‬ 15, P ‫؍‬ 0.48). These findings fail to support previous work by others suggesting the presence of allelic association between the markers D22S278 and D22S283 and schizophrenia.

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