No correlation between tissue concentration and plasma levels of invasion factors urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1
✍ Scribed by M Bader; I Witzel; V Müller; F Jänicke; F Thomssen
- Book ID
- 118622359
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 184 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1359-6349
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An ELISA has been developed for the assessment of complexes between the urokinase-type (uPA) and the tissuetype plasminogen (tPA) activators with their inhibitor type-1 (PAI-1) in cell-culture medium and cytosolic extracts of breast tumours. The ''4-stage/2-site'' ELISA involves 2 polyclonal antibod
Elevated levels of expression of the urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 have shown to be related to poor prognosis in a variety of cancer types. In the present study, cytosolic levels of uPA and PAI-1 were determined with enzyme-linked immunosorbent assays in cytosols