Mutational analysis of the genes encoding urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in advanced ovarian cancer

Dedifferentiation of serous ovarian canc

Dedifferentiation of serous ovarian cancer from cystic to solid tumors is associated with increased expression of mRNA for urokinase plasminogen activator (uPA), its receptor (uPAR) and its inhibitor (PAI-1)

✍ Christer Borgfeldt; Stefan R. Hansson; Barbro Gustavsson; Anna Måsbäck; Bertil C 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 337 KB

The plasminogen activating system is involved in tumor growth and metastasis by degradation of extracellular matrix, and modulation of cell adhesion and migration. Benign and well-differentiated malignant ovarian tumors present as cystic lesions with preserved glandular morphology, whereas poorly di