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No Contribution of an Inductive Effect to Secondary Deuterium Isotope Effects on Acidity

✍ Scribed by Prof. Charles L. Perrin; Agnes Flach

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
274 KB
Volume
50
Category
Article
ISSN
0044-8249

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✦ Synopsis

Isotope effects are observed when a reaction rate or equilibrium constant changes as a result of isotopic substitution. [1] They continue to be used as valuable tools to provide insight into molecular structure and reactivity. [2] Secondary isotope effects are those in which the bond to the isotope remains intact. Their origin continues to be an area of investigation. [3] Herein we address the origin of secondary deuterium isotope effects on acidity.

Deuterium isotope effects on acidities are expressed as K a H /K a D or as DpK = Àlog 10 (K a H

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