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No-carrier-added, 18F-labelling of a cholesterol derivative, used in detection of adrenal malignancies

✍ Scribed by Amir Reza Jalilian; Maria Bineshmarvasti; Hamid Rafii; Hossein Afarideh; Abbas Shafiee

Publisher: John Wiley and Sons
Year: 2001
Tongue: French
Weight: 104 KB
Volume: 44
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.496

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✦ Synopsis

Abstract

[^18^F]Cholesteryl 4‐(fluoromethyl)benzoate 6b was prepared from 3‐cholesteryl [(4‐nitrobenzenesulfonyl)oxymethyl]benzoate in one step using K^+^‐Kryptofix 2.2.2, as counter ion and acetonitrile as the solvent at 40–60°C. The product was isolated by HPLC in 75% (decay corrected) radiochemical yield with a radiochemical purity of more than 90% in 30 min (specific radioactivity 2000–2500 Ci/mmol). Biodistribution studies in mice showed that a high target/non‐target ratio of radioactivity was obtained in adrenal and ovaries. Copyright © 2001 John Wiley & Sons, Ltd.

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