No-carrier-added 18F-chemistry of radiopharmaceuticals
β Scribed by H.H. Coenen
- Publisher
- Elsevier Science
- Year
- 1988
- Weight
- 57 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0883-2889
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π SIMILAR VOLUMES
3-N-([18F]fluoroalkyl)spiperone derivatives (2,3) can be prepared by N-alkylation of spiperone (1) with fluoroalkyl halides. The fluoroalkylating species 2-[18F]fluoroethyl bromide (7), 3-[18F]fluoropropyl bromide (8) and 4-[18F]fluorobutyl bromide (9) were prepared by [18F]fluoride ion displacement
No-carrier-added trimethylsilyl[18F]fluoride (TMS[18F]F) was rapidly liberated from a variety of dry supports containing unreactive [18F]fluoride by simply heating with neat bistrimethylsilylsulfate. The supports included calcium phosphate, anion exchange resins, alumina, borosilicate and porous car