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No association between the DRD3 Ser9Gly polymorphism and schizophrenia

✍ Scribed by Ferid Fathalli; Guy A. Rouleau; Lan Xiong; Karim Tabbane; Chawki Benkelfat; Rosherrie Deguzman; Danics Zoltan; Samarthji Lal; Sarogini D’cruz; Ridha Joober


Book ID
119363197
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
179 KB
Volume
98
Category
Article
ISSN
0920-9964

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As part of the European Multicentre Association Study of Schizophrenia (EMASS), we studied polymorphisms in the dopamine DRD2 and DRD3 receptor genes. The EMASS collaboration was established to create a large, statistically powerful sample of schizophrenic patients and controls from different Europe

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Dopamine D3 receptor (DRD3) was demonstrated to have important implications in schizophrenia, because it binds antipsychotic drugs and is abundant in the limbic system of the brain. Several groups attempted to find an association between a serine-to-glycine polymorphism at codon 9 of the DRD3 gene (