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The dopamine D3 receptor (DRD3) Ser9Gly polymorphism and schizophrenia: a haplotype relative risk study and association with clozapine response

โœ Scribed by Malhotra, A K; Goldman, D; Buchanan, R W; Rooney, W; Clifton, A; Kosmidis, M H; Breier, A; Pickar, D

Book ID
110058812
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
48 KB
Volume
3
Category
Article
ISSN
1359-4184

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European multicentre association study o
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As part of the European Multicentre Association Study of Schizophrenia (EMASS), we studied polymorphisms in the dopamine DRD2 and DRD3 receptor genes. The EMASS collaboration was established to create a large, statistically powerful sample of schizophrenic patients and controls from different Europe

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Further evidence of no association between Ser9Gly polymorphism of dopamine D3 receptor gene and schizophrenia
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Dopamine D3 receptor (DRD3) was demonstrated to have important implications in schizophrenia, because it binds antipsychotic drugs and is abundant in the limbic system of the brain. Several groups attempted to find an association between a serine-to-glycine polymorphism at codon 9 of the DRD3 gene (