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No association between the COMT VAL158MET polymorphism and antipsychotic response in schizophrenia

✍ Scribed by D.J. Mueller; R. Hwang; J. Volavka; J.A. Lieberman; J.L. Kennedy

Book ID: 119555727
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 132 KB
Volume: 60
Category: Article
ISSN: 0920-9964
DOI: 10.1016/s0920-9964(03)80643-6

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## Abstract Schizophrenia is a complex disorder with a multifactorial polygenic inheritance with several genes conferring susceptibility at many genetic locations, each with a small effect. An attractive candidate gene for schizophrenia is the catechol‐__O__‐methyltransferase (__COMT__) gene, which