No association between TAU haplotype and Alzheimer's disease in population or clinic based series or in familial disease
✍ Scribed by Matt Baker; Daniel Graff-Radford; Fabienne Wavrant DeVrièze; Neill Graff-Radford; Ronald C Petersen; Emre Kokmen; Brad Boeve; Liisa Myllykangas; Tuomo Polvikoski; Raimo Sulkava; Auli Verkoniemmi; Pentti Tienari; Matti Haltia; John Hardy; Mike Hutton; Jordi Perez-Tur
- Book ID
- 117470723
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 74 KB
- Volume
- 285
- Category
- Article
- ISSN
- 0304-3940
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Mutations in the Presenilin 1 (PS1) gene on chromosome 14 cause most early-onset familial Alzheimer's disease (AD). An intronic polymorphism in the PS1 gene was recently identified and reported to be associated with late-onset AD [Wragg et al., Lancet 347: 509-512, 1996]. The authors found an excess
## Wragg et al. [1996: Lancet 347:509-512] recorded an association between the intronbased presenilin 1 (PS1) genotype 1/1 and late-onset Alzheimer's disease (AD). This study was performed to determine if there is a similar association in the Chinese population. Ninety-one AD cases, 50 multiinfarc