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N,N-Dimethyl-2-[7-(methylaminosulfonylmethyl)-1-naphthyl]ethylamine, the Naphthalenic Bioisostere of Sumatriptan

✍ Scribed by Tinant, B. ;Declercq, J. P. ;Abdellaoui, H. ;Depreux, P. ;Lesieur, D.


Book ID
114511647
Publisher
International Union of Crystallography
Year
1995
Tongue
English
Weight
311 KB
Volume
51
Category
Article
ISSN
0108-2701

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## Abstract The synthesis of the analgesic compound __N,N__‐dimethyl‐2‐(1‐phenyl‐2,5‐cyclohexadien‐1‐yl)ethylamine (**1**) is described. Its structural relation to morphine and its pharmacological activity is shortly discussed. The isolation of three mesembrinelike metabolites of **1** from the pla