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The Synthesis of n,n-Dimethyl-2-(1-phenyl-2,5-cyclohexadien-1-yl)-ethylamine and of Mesembrine-Like Metabolites of this Potential Analgesic

✍ Scribed by Peter M. Müller; Rudolf Pfister

Book ID: 102858755
Publisher: John Wiley and Sons
Year: 1983
Tongue: German
Weight: 607 KB
Volume: 66
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19830660308

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✦ Synopsis

Abstract

The synthesis of the analgesic compound N,N‐dimethyl‐2‐(1‐phenyl‐2,5‐cyclohexadien‐1‐yl)ethylamine (1) is described. Its structural relation to morphine and its pharmacological activity is shortly discussed. The isolation of three mesembrinelike metabolites of 1 from the plasma of rats is reported along with synthetic work permitting the determination of the relative configuration of these metabolites.

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