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N,N-Dialkylated leucine enkephalins as potential .delta. opioid receptor antagonists

โœ Scribed by Lovett, Jane A.; Portoghese, Philip S.


Book ID
126182937
Publisher
American Chemical Society
Year
1987
Tongue
English
Weight
953 KB
Volume
30
Category
Article
ISSN
0022-2623

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As part of an effort to develop peptide-based affinity labels for opioid receptors, [Leu(5)]enkephalin (LeuEnk) and DTLET (Tyr-D-Thr-Gly-Phe-Leu-Thr), potent agonists for delta receptors, were selected as the parent peptides for further modification. The affinity label derivatives were prepared usin