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NMR study of the synthesis of 17O-enriched acetic acid by hydrolysis of acetic anhydride with 17O-enriched water

✍ Scribed by Heidi M. Hultman; Kristina Djanashvili; Joop A. Peters

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 127 KB
Volume: 41
Category: Article
ISSN: 0749-1581
DOI: 10.1002/mrc.1266

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✦ Synopsis

Abstract

^17^O‐enriched acetic acid (2.5% in ^17^O) was synthesized by hydrolysis of acetic anhydride with ^17^O‐enriched water. The reaction was monitored by ^17^O and ^1^H NMR spectroscopy. Acetic anhydride, ^17^O‐enriched in both the ether and the carbonyl oxygens, was observed as an intermediate. This can be ascribed to competition between acetic acid and water for nucleophilic attack on acetic anhydride. Copyright © 2003 John Wiley & Sons, Ltd.

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