✦ LIBER ✦

A simple and rapid method for the synthesis of nucleoside 5′-monophosphates enriched with 17O or 18O on the phosphate group

✍ Scribed by R.S. Goody

Publisher: Elsevier Science
Year: 1982
Tongue: English
Weight: 192 KB
Volume: 119
Category: Article
ISSN: 0003-2697
DOI: 10.1016/0003-2697(82)90592-9

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✦ Synopsis

A simple and rapid procedure for the synthesis of AMP"0, AMP'sO, and the corresponding guanosine derivatives is described. The method is based on the intermediate production of P"OC13 or P'*OClj from PCIs, but does not involve their isolation, so that all steps involved can be carried out in the same reaction vessel. The overall yields are in the region of 45%.