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NMR studies of the luteinizing hormone-releasing hormone (LH-RH) decapeptide in DMSO solution

✍ Scribed by Luigi Calzolai; Elena Gaggelli; Gianni Valensin; Antonella Maccotta

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 508 KB
Volume: 32
Category: Article
ISSN: 0749-1581
DOI: 10.1002/mrc.1260320908

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✦ Synopsis

Abstract

The structure of LH‐RH in DMSO solution was studied using 2D NMR experiments at 600 MHz. The ^13^C NMR spectrum was completely assigned by the combined use of ^1^H‐detected heteronuclear multiple‐quantum coherence and ^1^H‐detected multiple‐bond heteronuclear multiple‐quantum coherence. Measured ^1^J(CH) values were used to obtain the possible sets of Φ and Ψ dihedral angles. These features, together with some relevant dipolar interactions observed in the ROESY spectrum, were interpreted to provide evidence of some degree of intramolecular structuring.

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