NMR studies of the inclusion complex between β-cyclodextrin and paroxetine
✍ Scribed by Andrea Bernini; Ottavia Spiga; Arianna Ciutti; Maria Scarselli; Giuseppe Bottoni; Paolo Mascagni; Neri Niccolai
- Book ID
- 113591348
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 162 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0928-0987
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## Abstract The interaction between doxepin, a member of the tricyclic antidepressant (TCA) class of drugs, with β‐cyclodextrin (β‐CD) was investigated using NMR. Several TCAs have been reported to form a complex with β‐CD having 1:1 stoichiometry. Previous results from UV‐visible spectroscopy, flu
The interaction of a nonsteroidal anti-inflammatory drug, naproxen, with \(\beta\)-CD has been studied by several analytical techniques, including 1-D and 2-D proton NMR, fluorescence spectroscopy, and FAB-MS. The negative ion FAB-MS confirmed the existence of a 1:1 inclusion complex of naproxen and
The inclusion complexes of 2-, 3-, and 4-hydroxypyridines with @cyclodextrin in aqueous solution have been studied by high field 'H NMR. All complexes showed a 1: 1 stoichiometry and the apparent association constants reflected the polarity of the guest compounds in a qualitative fashion. The inclus