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A 1H NMR study of inclusion complex formation between β-cyclodextrin and monohydroxypyridines

✍ Scribed by Marina Cotta Ramusino; Simona Pichini

Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
437 KB
Volume
259
Category
Article
ISSN
0008-6215

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✦ Synopsis

The inclusion complexes of 2-, 3-, and 4-hydroxypyridines with @cyclodextrin in aqueous solution have been studied by high field 'H NMR. All complexes showed a 1: 1 stoichiometry and the apparent association constants reflected the polarity of the guest compounds in a qualitative fashion. The inclusion process has been shown to markedly affect the tautomeric equilibrium between the lactim and lactam forms of 3-hydroxypyridine with a preferential inclusion of the former, less polar tautomer.

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