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NMR relaxation rates and blood oxygenation level

✍ Scribed by M.-E Meyer; Olivier Yu; Bernard Eclancher; Daniel Grucker; Jacques Chambron

Book ID
102952569
Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
753 KB
Volume
34
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

A linear relationship between the proton relaxation rates and the fraction of deoxyhemoglobin of circulating whole blood (f~Hb~) has been established in vitro at 4.7 T. These results have been interpreted on the basis of the additivity of relaxation rates. The slope of the lines of transverse relaxation rates (R~2~) versus f~Hb~ was found to increase with interpulse delay in Carr‐Purcell Meiboom‐Gill (CPMG) experiments. The Luz‐Mei‐boom relation applied to this interpulse delay dependence of R~2~ suggests a two‐site chemical exchange rather than a diffusion mechanism. The 1‐ms water proton exchange time derived from these observations has been interpreted in terms of exchange between exchangeable protons close to the paramagnetic center of hemoglobin and protons of bulk water.

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