✦ LIBER ✦

NMR metabolomics and drug discovery

✍ Scribed by Robert Powers

Book ID: 102951028
Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 544 KB
Volume: 47
Category: Article
ISSN: 0749-1581
DOI: 10.1002/mrc.2461

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✦ Synopsis

Abstract

NMR is an integral component of the drug discovery process with applications in lead discovery, validation, and optimization. NMR is routinely used for fragment‐based ligand affinity screens, high‐resolution protein structure determination, and rapid protein‐ligand co‐structure modeling. Because of this inherent versatility, NMR is currently making significant contributions in the burgeoning area of metabolomics, where NMR is successfully being used to identify biomarkers for various diseases, to analyze drug toxicity and to determine a drug's in vivo efficacy and selectivity. This review describes advances in NMR‐based metabolomics and discusses some recent applications. Copyright © 2009 John Wiley & Sons, Ltd.

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